Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6937291 | 0.89 | MEN1 (0.41) | MAPTLMNAHTTABCC9ABCC8 | |
| SCHEMBL6938587 | 0.89 | SLC6A2 (0.41) | MAPTLMNASLC9A1HTTABCC9 | |
| SCHEMBL6936990 | 0.87 | SLC9A1 (0.42) | MAPTLMNASLC9A1GAA | |
| SCHEMBL6936874 | 0.85 | PDE7A (0.47) | MAPTLMNASLC9A1 | |
| SCHEMBL6932534 | 0.85 | SLC9A1 (0.44) | SLC9A1SLC6A2SLC6A4 | |
| SCHEMBL6935058 | 0.82 | MAPT (0.41) | MAPTLMNASLC9A1HTTSLC6A2 | |
| SCHEMBL6935160 | 0.81 | SLC9A1 (0.54) | SLC9A1 | |
| SCHEMBL6932470 | 0.81 | ALDH1A1 (0.52) | MAPTLMNASLC9A1HTT | |
| SCHEMBL6935504 | 0.79 | MAPT (0.45) | MAPTLMNAHTT | |
| SCHEMBL6932140 | 0.79 | BCL2L1 (0.53) | LMNASLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758644-B1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |
| EP-0758644-A1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1997-02-19 | — | — | EP | disclosed |