Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6930144 | 0.88 | RAB9A (0.38) | RAB9AKDM4EHPGDNPC1GLA | |
| SCHEMBL8769700 | 0.77 | MAPT (0.39) | RAB9AKDM4EHPGDNPC1TSHR | |
| SCHEMBL6933209 | 0.69 | PKM (0.41) | RAB9AKDM4EHPGDNPC1GLA | |
| SCHEMBL8769683 | 0.68 | RAB9A (0.39) | RAB9AKDM4EHPGDNPC1GLA | |
| SCHEMBL3841327 | 0.68 | PDE5A (0.59) | — | |
| SCHEMBL6927520 | 0.63 | MAPT (0.36) | KDM4EHPGDTSHRKMT2AALDH1A1 | |
| SCHEMBL7132309 | 0.62 | KDM4E (0.45) | KDM4EHPGDKMT2AALDH1A1MEN1 | |
| SCHEMBL9426298 | 0.61 | FKBP1A (0.53) | RAB9AKDM4EHPGDNPC1GLA | |
| SCHEMBL10195739 | 0.60 | FKBP1A (0.72) | RAB9AFKBP1ATSHRKMT2AALDH1A1 | |
| SCHEMBL23085706 | 0.59 | HPGD (0.43) | RAB9AKDM4EHPGDNPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1365806-A2 | USE OF NO ACTTIVATORS FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS | JOHNS HOPKINS UNIVERSITY (US) | 2003-12-03 | — | — | EP | claimed |
| WO-2001078781-A9 | METHODS FOR PREVENTION AND TREATMENT OF GASTROINTESTINAL DISORDERS | UNIV JOHNS HOPKINS (US) | 2002-07-25 | — | — | WO | claimed |
| WO-2001078781-A2 | METHODS FOR PREVENTION AND TREATMENT OF GASTROINTESTINAL DISORDERS | JOHNS HOPKINS UNIVERSITY (US) | 2001-10-25 | — | — | WO | claimed |