Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7795495 | 0.83 | NPC1 (0.48) | RAB9ANPC1KDM4EHPGDPDE5A | |
| SCHEMBL3841327 | 0.77 | PDE5A (0.59) | PDE5A | |
| SCHEMBL6930144 | 0.69 | RAB9A (0.38) | RAB9ANPC1KDM4EHPGDGLA | |
| SCHEMBL6933205 | 0.68 | RAB9A (0.39) | RAB9ANPC1KDM4EHPGDGLA | |
| SCHEMBL6933209 | 0.63 | PKM (0.41) | RAB9ANPC1KDM4EHPGDGLA | |
| SCHEMBL6638843 | 0.62 | PDE5A (0.54) | PDE5ALMNAALDH1A1HTTKMT2A | |
| SCHEMBL9097067 | 0.61 | PDE5A (0.47) | PDE5A | |
| SCHEMBL10195739 | 0.60 | FKBP1A (0.72) | RAB9AFKBP1ATSHRTP53ALDH1A1 | |
| SCHEMBL9426298 | 0.60 | FKBP1A (0.53) | RAB9ANPC1KDM4EHPGDGLA | |
| SCHEMBL8984884 | 0.59 | LMNA (0.63) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793498-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF IMPOTENCE | Pfizer Limited (GB) | 1997-09-10 | — | — | EP | claimed |
| WO-1996016657-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF IMPOTENCE | PFIZER LIMITED (GB) | 1996-06-06 | — | — | WO | claimed |
| EP-0793498-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF IMPOTENCE | Pfizer Limited (GB) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016657-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF IMPOTENCE | PFIZER LIMITED (GB) | 1996-06-06 | — | — | WO | disclosed |