Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.56 |
| ▸ | HTR7 | P34969 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938695 | 0.88 | MAPT (0.53) | MAPTHTR7KMT2AMAPK1MEN1 | |
| SCHEMBL6938506 | 0.86 | PRMT5 (0.46) | MAPTMAPK1ALDH1A1ABCB1LMNA | |
| SCHEMBL1377207 | 0.84 | DRD3 (0.53) | MAPTHTR7KMT2AMAPK1MEN1 | |
| SCHEMBL6934131 | 0.83 | ADRB3 (0.44) | MAPTKMT2AMAPK1MEN1ALDH1A1 | |
| SCHEMBL6935782 | 0.82 | ADRB3 (0.45) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL5459027 | 0.81 | MAPT (0.56) | MAPTHTR7KMT2AMAPK1MEN1 | |
| SCHEMBL13898865 | 0.76 | MAPT (0.59) | MAPTHTR7KMT2AMAPK1MEN1 | |
| SCHEMBL11163940 | 0.75 | MAPT (0.62) | MAPTHTR7KMT2AMAPK1MEN1 | |
| SCHEMBL8613867 | 0.74 | MAPT (0.82) | MAPTHTR7KMT2AMAPK1MEN1 | |
| SCHEMBL7258918 | 0.74 | MEN1 (0.57) | MAPTKMT2AMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003509432-A | — | — | 2003-03-11 | — | — | JP | claimed |
| EP-1216250-A1 | THIENOISOXAZOLYL AND THIENYLPYRRAZOLYL PHENOXY SUBSTITUTED PROPYL DERIVATIVES USEFUL AS D4 ANTAGONISTS | Aventis Pharmaceuticals Inc. (US) | 2002-06-26 | — | — | EP | claimed |
| WO-2001019833-A1 | THIENOISOXAZOLYL- AND THIENYLPYRRAZOLYL-PHENOXY SUBSTITUTED PROPYL DERIVATIVES USEFUL AS D4 ANTAGONISTS | AVENTIS PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | claimed |