Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938695 | 0.90 | MAPT (0.53) | PRMT5WDR77ABCB1MAPTALDH1A1 | |
| SCHEMBL6934068 | 0.86 | MAPT (0.56) | ABCB1MAPTALDH1A1LMNAGAA | |
| SCHEMBL5463844 | 0.83 | PRMT5 (0.46) | PRMT5WDR77HSP90AB1CACNA1GKCNH2 | |
| SCHEMBL6934131 | 0.83 | ADRB3 (0.44) | PRMT5WDR77CACNA1GABCB1MAPT | |
| SCHEMBL6935782 | 0.79 | ADRB3 (0.45) | PRMT5WDR77CACNA1GABCB1MAPT | |
| SCHEMBL1379788 | 0.75 | DRD2 (0.45) | — | |
| SCHEMBL5460355 | 0.72 | MAPT (0.53) | PRMT5WDR77ABCB1MAPTALDH1A1 | |
| SCHEMBL5469975 | 0.71 | HTR7 (0.49) | PRMT5WDR77HSP90AB1ABCB1MAPT | |
| SCHEMBL1377207 | 0.71 | DRD3 (0.53) | MAPTMAPK1 | |
| SCHEMBL13902765 | 0.71 | ABCB1 (0.46) | HSP90AB1ABCB1MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003509432-A | — | — | 2003-03-11 | — | — | JP | claimed |
| EP-1216250-A1 | THIENOISOXAZOLYL AND THIENYLPYRRAZOLYL PHENOXY SUBSTITUTED PROPYL DERIVATIVES USEFUL AS D4 ANTAGONISTS | Aventis Pharmaceuticals Inc. (US) | 2002-06-26 | — | — | EP | claimed |
| WO-2001019833-A1 | THIENOISOXAZOLYL- AND THIENYLPYRRAZOLYL-PHENOXY SUBSTITUTED PROPYL DERIVATIVES USEFUL AS D4 ANTAGONISTS | AVENTIS PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | claimed |