Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 7/20 | 0.53 |
| ▸ | DRD2 | P14416 | 7/20 | 0.53 |
| ▸ | HTR1A | P08908 | 5/20 | 0.53 |
| ▸ | HTR2A | P28223 | 4/20 | 0.53 |
| ▸ | HRH1 | P35367 | 4/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1376598 | 0.89 | DRD2 (0.47) | DRD3DRD2HTR1AHTR2AHRH3 | |
| SCHEMBL1379788 | 0.88 | DRD2 (0.45) | DRD2HTR1AHTR2A | |
| SCHEMBL7635672 | 0.88 | HRH3 (0.52) | HRH1TSHRHRH3 | |
| SCHEMBL6934068 | 0.84 | MAPT (0.56) | MEN1MAPTMAPK1KMT2ATDP1 | |
| SCHEMBL1377693 | 0.83 | LTA4H (0.55) | HRH3 | |
| SCHEMBL7632638 | 0.83 | L3MBTL1 (0.47) | DRD3DRD2HTR1AHTR2AHRH1 | |
| SCHEMBL7686431 | 0.82 | BACE1 (0.56) | HRH3 | |
| SCHEMBL6070212 | 0.80 | DRD3 (0.53) | DRD3DRD2HTR1AHTR2AHRH1 | |
| SCHEMBL7638803 | 0.79 | CYP1A2 (0.38) | CYP1A2CYP2C9MAPK1CYP2C19CXCR1 | |
| SCHEMBL7631973 | 0.78 | MAOA (0.38) | CYP1A2CYP2C9MAPK1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4717306-B2 | — | — | 2011-07-06 | — | — | JP | claimed |
| JP-2003509431-A | — | — | 2003-03-11 | — | — | JP | claimed |
| EP-1216249-A2 | THIENOISOXAZOLE PHENOXY UNSUBSTITUTED ETHYL AND PROPYL DERIVATIVES USEFUL AS D4 ANTAGONISTS | Aventis Pharmaceuticals Inc. (US) | 2002-06-26 | — | — | EP | claimed |
| WO-2001019832-A2 | THIENOISOXAZOLE PHENOXY UNSUBSTITUTED ETHYL AND PROPYL DERIVATIVES USEFUL AS D4 ANTAGONISTS | AVENTIS PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | claimed |