Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TDO2 | P48775 | 2/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CTRC | Q99895 | 1/20 | 0.30 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8921348 | 0.78 | ENPP3 (0.41) | ALDH1A1RAB9ANPC1SMN1; SMN2NOTUM | |
| SCHEMBL28031803 | 0.78 | NPC1 (0.39) | RAB9ANPC1SMN1; SMN2TDO2NOTUM | |
| SCHEMBL1654513 | 0.78 | NOTUM (0.39) | ALDH1A1RAB9ANPC1SMN1; SMN2TDO2 | |
| SCHEMBL16060614 | 0.73 | DYRK1A (0.47) | ALDH1A1RAB9ANPC1SMN1; SMN2TDO2 | |
| SCHEMBL2821405 | 0.71 | NOTUM (0.38) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL69514 | 0.71 | SMN1; SMN2 (0.40) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL2182857 | 0.71 | KDM4E (0.48) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL2821209 | 0.71 | ALDH1A1 (0.44) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL4719301 | 0.69 | ENPP3 (0.43) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL8183045 | 0.68 | ALDH1A1 (0.43) | ALDH1A1RAB9ANPC1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 259 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230374014-A1 | CGAS INHIBITING TRIAZOLOPYRIMIDONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-11-23 | — | — | US | claimed |
| EP-4153593-A1 | CGAS INHIBITING TRIAZOLOPYRIMIDONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-03-29 | — | — | EP | claimed |
| CN-114835736-A | Compound, display panel and display device | 武汉天马微电子有限公司 | 2022-08-02 | — | — | CN | claimed |
| WO-2021233852-A1 | CGAS INHIBITING TRIAZOLOPYRIMIDONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-11-25 | — | — | WO | claimed |
| CN-107531690-B | 4,5,6, 7-tetrahydro-1H-pyrazolo [4,3-c ] pyridin-3-amine compounds as CBP and/or EP300 inhibitors | 基因泰克公司 | 2020-11-06 | — | — | CN | claimed |
| EP-3224258-A1 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | Genentech, Inc. (US) | 2017-10-04 | — | — | EP | claimed |
| WO-2016086200-A9 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-23 | — | — | WO | claimed |
| WO-2016086200-A1 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-02 | — | — | WO | claimed |
| CN-102686596-A | Azabicyclo[2.2.1] heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands | BRISTOL MYERS SQUIBB CO | 2012-09-19 | — | — | CN | claimed |
| CN-102686595-A | Azabicyclic compounds as alpha-7 nicotinic acetylcholine receptor ligands | BRISTOL MYERS SQUIBB CO | 2012-09-19 | — | — | CN | claimed |
| US-6121300-A | IN A TOPICAL COSMETIC AS SKIN ELASTICITY IMPROVER OR WRINKLE REDUCER; COMPOUNDS SUCH AS 3-(2-(3-PHENYL-5-ISOXAZOLYL)-2-OXOETHYL)-THIAZOLIUM; ADMINSISTERING TO TREAT CATARACTS, PROTEIN AGING AND DIABETES | SYNVISTA THERAPEUTICS, INC. | 2000-09-19 | — | — | US | claimed |
| WO-2000027395-A1 | REVERSING ADVANCED GLYCOSYLATION CROSS-LINKS USING HETEROCYCLIC-SUBSTITUTED THIAZOLIUM SALTS | ALTEON, INC. (US) | 2000-05-18 | — | — | WO | claimed |
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | claimed |
| US-5547984-A | FUNGICIDES | ROHM AND HAAS COMPANY (US) | 1996-08-20 | — | — | US | claimed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | claimed |
| EP-0170498-B1 | N-ACETONYL-SUBSTITUTED-AMIDES, COMPOSITIONS CONTAINING THEM AND THEIR USE IN COMBATING FUNGI | ROHM AND HAAS COMPANY (US) | 1991-09-11 | — | — | EP | claimed |
| US-4863940-A | N-acetonyl-substituted amides and phytopathogenic fungicidal use thereof | ROHM AND HAAS (US) | 1989-09-05 | — | — | US | claimed |
| EP-0150433-B1 | PROCESS FOR THE PREPARATION OF INSATURATED KETONES | BASF Aktiengesellschaft (DE) | 1986-12-30 | — | — | EP | claimed |
| EP-0170498-A2 | N-acetonyl-substituted-amides, compositions containing them and their use in combating fungi | ROHM AND HAAS COMPANY (US) | 1986-02-05 | — | — | EP | claimed |
| EP-0150433-A2 | Process for the preparation of insaturated ketones | BASF Aktiengesellschaft (DE) | 1985-08-07 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230374014-A1 | CGAS INHIBITING TRIAZOLOPYRIMIDONE DERIVATIVES | CGAS, GLS2, GBA3 | ALDH1A1 928/4885RAB9A 3343/4885NPC1 1805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.