Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.70 |
| ▸ | MAOB | P27338 | 9/20 | 0.68 |
| ▸ | CXCL12 | P48061 | 2/20 | 0.68 |
| ▸ | MAOA | P21397 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | SNCA | P37840 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | JUN | P05412 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934332 | 1.00 | CYP1B1 (0.70) | CYP1B1MAOBCXCL12MAOAMAPT | |
| SCHEMBL6934856 | 0.87 | CYP1B1 (0.70) | CYP1B1MAOBMAPTALDH1A1CYP1A1 | |
| 4',4-Dichlorochalcone SCHEMBL659210 | 0.87 | MAOB (0.86) | CYP1B1MAOBCXCL12MAOAMAPT | |
| 4',4-Dichlorochalcone SCHEMBL659211 | 0.87 | MAOB (0.86) | CYP1B1MAOBCXCL12MAOAMAPT | |
| SCHEMBL6934854 | 0.87 | CYP1B1 (0.70) | CYP1B1MAOBMAPTALDH1A1CYP1A1 | |
| 4',4-Dichlorochalcone SCHEMBL11819257 | 0.85 | MAOB (0.83) | CYP1B1MAOBCXCL12MAOAMAPT | |
| 4',4-Dichlorochalcone SCHEMBL11819602 | 0.85 | MAOB (0.83) | CYP1B1MAOBCXCL12MAOAMAPT | |
| 4',4-Dichlorochalcone SCHEMBL11819608 | 0.85 | MAOB (0.83) | CYP1B1MAOBCXCL12MAOAMAPT | |
| 4',4-Dichlorochalcone SCHEMBL11819262 | 0.85 | MAOB (0.83) | CYP1B1MAOBCXCL12MAOAMAPT | |
| SCHEMBL1603994 | 0.84 | F3 (0.76) | CYP1B1MAOBCXCL12MAOAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649604-B2 | Analgesics; antidiabetic agents; antiinflamamtory agents | AMGEN INC. | 2003-11-18 | — | — | US | disclosed |
| US-20030073704-A1 | Substituted pyridone compounds and methods of use | AMGEN INC. | 2003-04-17 | — | — | US | disclosed |
| US-6420385-B1 | INFLAMMATORY, PAIN AND DIABETES DISEASES, | AMGEN INC. | 2002-07-16 | — | — | US | disclosed |
| US-6096753-A | Substituted pyrimidinone and pyridone compounds and methods of use | AMGEN INC. (US) | 2000-08-01 | — | — | US | disclosed |
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073704-A1 | Substituted pyridone compounds and methods of use | IL6, IL1B, IL1A | CYP1B1 115/4885MAOB 1221/4885CXCL12 624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.