Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | SELE | P16581 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7075292 | 0.89 | PDE7A (0.46) | SLC9A1SMN1; SMN2MAPTPDE7A | |
| SCHEMBL6936990 | 0.89 | SLC9A1 (0.42) | SLC9A1ALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL7074544 | 0.89 | ALDH1A1 (0.49) | SLC9A1ALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL27372107 | 0.88 | ALDH1A1 (0.41) | ALDH1A1POLBSMN1; SMN2MAPTPDE7A | |
| SCHEMBL6938587 | 0.86 | SLC6A2 (0.41) | SLC9A1ALDH1A1POLBMAPTSLC6A2 | |
| SCHEMBL6935074 | 0.84 | SLC6A2 (0.42) | SLC9A1ALDH1A1SMN1; SMN2MAPTSLC6A2 | |
| SCHEMBL6935937 | 0.83 | SLC6A4 (0.40) | SLC9A1POLBSMN1; SMN2MAPTPDE7A | |
| SCHEMBL6938143 | 0.83 | BCL2L1 (0.48) | SLC9A1ALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL6938107 | 0.83 | MAPT (0.44) | SLC9A1ALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL6930504 | 0.81 | MAPT (0.38) | SLC9A1ALDH1A1POLBMAPTPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758644-B1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |
| EP-0758644-A1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1997-02-19 | — | — | EP | disclosed |