Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.38 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6930504 | 0.89 | MAPT (0.38) | SLC6A4LMNAMAPTSLC9A1HTT | |
| SCHEMBL6938838 | 0.89 | MAPT (0.40) | SLC6A2SLC6A4LMNAMAPTSLC9A1 | |
| SCHEMBL6935462 | 0.86 | SLC9A1 (0.40) | SLC6A2SLC6A4SLC6A3MAPTSLC9A1 | |
| SCHEMBL7075292 | 0.85 | PDE7A (0.46) | LMNAMAPTSLC9A1 | |
| SCHEMBL6935163 | 0.85 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3SLC9A1ALDH1A1 | |
| SCHEMBL6932303 | 0.83 | MAPT (0.40) | SLC6A2SLC6A4SLC6A3LMNAMAPT | |
| SCHEMBL6934420 | 0.82 | SLC6A2 (0.43) | SLC6A2SLC6A4 | |
| SCHEMBL7074544 | 0.81 | ALDH1A1 (0.49) | LMNAMAPTSLC9A1HTTALDH1A1 | |
| SCHEMBL6938107 | 0.80 | MAPT (0.44) | LMNAMAPTSLC9A1HTTALDH1A1 | |
| SCHEMBL6938143 | 0.80 | BCL2L1 (0.48) | MAPTSLC9A1ALDH1A1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758644-B1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |
| EP-0758644-A1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1997-02-19 | — | — | EP | disclosed |