Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934463 | 0.89 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3MAPTALDH1A1 | |
| SCHEMBL6935937 | 0.88 | SLC6A4 (0.40) | SLC6A2SLC6A4SLC6A3MAPTSLC9A1 | |
| SCHEMBL27364389 | 0.87 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3MAPTALDH1A1 | |
| SCHEMBL7074544 | 0.87 | ALDH1A1 (0.49) | MAPTALDH1A1SLC9A1SMN1; SMN2LMNA | |
| SCHEMBL6935462 | 0.84 | SLC9A1 (0.40) | SLC6A2SLC6A4SLC6A3MAPTALDH1A1 | |
| SCHEMBL6933378 | 0.81 | LMNA (0.46) | SLC6A4MAPTALDH1A1SLC9A1RAB9A | |
| SCHEMBL8796619 | 0.81 | PDE7A (0.50) | SLC6A2SLC6A4SLC6A3MAPTSLC9A1 | |
| SCHEMBL6935490 | 0.80 | SLC9A1 (0.39) | SLC9A1 | |
| SCHEMBL6935236 | 0.80 | SLC9A1 (0.51) | SLC9A1 | |
| SCHEMBL6938107 | 0.80 | MAPT (0.44) | MAPTALDH1A1SLC9A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758644-B1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |
| EP-0758644-A1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1997-02-19 | — | — | EP | disclosed |