Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.47 |
| ▸ | FAP | Q12884 | 2/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.47 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.47 |
| ▸ | TPH1 | P17752 | 7/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934288 | 0.87 | PPARG (0.47) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL6931543 | 0.86 | CTSL (0.40) | ITGB3ITGA2BPTPN1SLC7A5 | |
| SCHEMBL6930581 | 0.85 | ITGB3 (0.47) | ITGB3ITGA2BSLC7A5 | |
| SCHEMBL6935590 | 0.83 | ITGA4 (0.48) | — | |
| SCHEMBL6930981 | 0.83 | ITGB1 (0.39) | TPH1ITGB3ITGA2BPTPN1 | |
| Tyrosine SCHEMBL7712095 | 0.82 | SLC7A5 (0.50) | DPP4TPH1SLC7A5 | |
| SCHEMBL597743 | 0.77 | LDHA (0.71) | TPH1LDHAITGB3ITGA2BPTPN1 | |
| SCHEMBL158667 | 0.77 | LDHA (0.71) | TPH1LDHAITGB3ITGA2BPTPN1 | |
| SCHEMBL126195 | 0.77 | LDHA (0.71) | TPH1LDHAITGB3ITGA2BPTPN1 | |
| Hydrochloric Acid SCHEMBL16446949 | 0.76 | LDHA (0.69) | TPH1LDHAITGB3ITGA2BPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984981-B1 | ANTI-INFLAMMATORY TYROSINE DERIVATIVES | CELLTECH THERAPEUTICS LTD (GB) | 2003-12-17 | — | — | EP | disclosed |
| US-6093696-A | N-ACETYL-D-THIOPROLINE-(O-2,6-DICHLOROBENZYL)-L-TYROSINE, FOR EXAMPLE; SELECTIVELY INHIBIT THE ALPHA 4 SUBGROUP OF INTEGRINS FROM BINDING TO THEIR LIGANDS; USE IN PROPHYLAXIS OR TREATMENT OF IMMUNE OR INFLAMMATORY DISEASES | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |