Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | ITK | Q08881 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CCR1 | P32246 | 1/20 | 0.50 |
| ▸ | CCR5 | P51681 | 1/20 | 0.50 |
| ▸ | CCR8 | P51685 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31537211 | 0.81 | GSK3B (0.58) | GSK3BAURKAAURKBITKKDM4E | |
| SCHEMBL6016016 | 0.81 | GSK3B (0.58) | GSK3BAURKAAURKBITKKDM4E | |
| SCHEMBL695324 | 0.80 | CCR1 (0.46) | GSK3BAURKAAURKBITKKDM4E | |
| SCHEMBL29470995 | 0.80 | GSK3B (0.61) | GSK3BAURKAAURKBITKKDM4E | |
| SCHEMBL308319 | 0.80 | GSK3B (0.61) | GSK3BAURKAAURKBITKKDM4E | |
| SCHEMBL695340 | 0.77 | AURKA (0.56) | GSK3BAURKAAURKBITKKDM4E | |
| SCHEMBL30289837 | 0.77 | GSK3B (0.55) | GSK3BAURKAAURKBITKKDM4E | |
| SCHEMBL28401656 | 0.76 | KDM4E (0.51) | GSK3BAURKAAURKBITKKDM4E | |
| SCHEMBL28784366 | 0.76 | ITK (0.57) | GSK3BAURKAAURKBITKKDM4E | |
| SCHEMBL701368 | 0.75 | CYP19A1 (0.59) | GSK3BAURKAAURKBITKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421825-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124108-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |