Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936000 | 1.00 | ABCG2 (0.80) | ABCG2CYP3A4CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL4254944 | 0.88 | ABCG2 (0.90) | ABCG2CYP3A4CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL4254947 | 0.88 | ABCG2 (0.90) | ABCG2CYP3A4CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL15631510 | 0.85 | ABCG2 (0.91) | ABCG2CYP3A4CYP2D6MEN1NPC1 | |
| SCHEMBL20339099 | 0.84 | ABCG2 (0.88) | ABCG2CYP3A4CYP2D6MEN1MAPT | |
| SCHEMBL20339098 | 0.84 | ABCG2 (0.88) | ABCG2CYP3A4CYP2D6MEN1MAPT | |
| SCHEMBL12484491 | 0.82 | ABCG2 (0.78) | ABCG2CYP3A4CYP1A1CYP1A2CYP1B1 | |
| Dilmefone SCHEMBL2109149 | 0.82 | ABCG2 (0.82) | ABCG2CYP3A4CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL12484495 | 0.82 | ABCG2 (0.78) | ABCG2CYP3A4CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL25237374 | 0.81 | ABCG2 (0.83) | ABCG2CYP3A4CYP2D6CYP1B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649604-B2 | Analgesics; antidiabetic agents; antiinflamamtory agents | AMGEN INC. | 2003-11-18 | — | — | US | disclosed |
| US-20030073704-A1 | Substituted pyridone compounds and methods of use | AMGEN INC. | 2003-04-17 | — | — | US | disclosed |
| US-6420385-B1 | INFLAMMATORY, PAIN AND DIABETES DISEASES, | AMGEN INC. | 2002-07-16 | — | — | US | disclosed |
| US-6096753-A | Substituted pyrimidinone and pyridone compounds and methods of use | AMGEN INC. (US) | 2000-08-01 | — | — | US | disclosed |
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |
| US-4294841-A | ANTIARRHYTHMIA AGENTS | PHARMINDUSTRIE (FR) | 1981-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073704-A1 | Substituted pyridone compounds and methods of use | IL6, IL1B, IL1A | ABCG2 1811/4885CYP3A4 340/4885CYP1A1 201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.