Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.51 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.51 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.48 |
| ▸ | RARB | P10826 | 6/20 | 0.48 |
| ▸ | THRA | P10827 | 7/20 | 0.47 |
| ▸ | THRB | P10828 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RARA | P10276 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10711276 | 0.91 | THRA (0.56) | RARBTHRATHRBMEN1KMT2A | |
| SCHEMBL6753083 | 0.80 | THRA (0.58) | RARBTHRATHRBMEN1KMT2A | |
| SCHEMBL4017551 | 0.78 | HSD17B3 (0.53) | ALDH1A1 | |
| SCHEMBL11781795 | 0.76 | CES2 (0.49) | MAPT | |
| SCHEMBL10984688 | 0.75 | THRA (0.59) | RARBTHRATHRBMEN1KMT2A | |
| SCHEMBL26239861 | 0.75 | ALDH1A1 (0.65) | MEN1KMT2AALDH1A1S1PR4S1PR1 | |
| SCHEMBL8500578 | 0.75 | ALDH1A1 (0.59) | CYP4A11CYP4F2ALDH1A1S1PR4S1PR1 | |
| SCHEMBL11267100 | 0.75 | CYP4A11 (0.50) | CYP4A11CYP4F2SPHK1RARBTHRA | |
| SCHEMBL8903662 | 0.74 | RARB (0.60) | RARBTHRATHRBMEN1KMT2A | |
| SCHEMBL154856 | 0.74 | CYP4A11 (0.51) | CYP4A11CYP4F2RARBTHRBPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |