Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 6/20 | 0.53 |
| ▸ | KCNQ1 | P51787 | 6/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 5/20 | 0.40 |
| ▸ | THRB | P10828 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6932420 | 0.87 | KCNE1 (0.45) | KCNE1KCNQ1KCNH2HTR2AHTR2C | |
| SCHEMBL6935178 | 0.78 | NPC1 (0.44) | KCNE1KCNQ1HTR2AHTR2CNPC1 | |
| SCHEMBL6936603 | 0.75 | LTA4H (0.38) | KCNE1KCNQ1KCNH2HTR2ANPC1 | |
| SCHEMBL6932454 | 0.73 | KCNE1 (0.33) | KCNE1KCNQ1HTR2AHTR2C | |
| SCHEMBL6602317 | 0.73 | KCNE1 (0.54) | KCNE1KCNQ1KCNH2 | |
| SCHEMBL6932849 | 0.71 | KCNE1 (0.45) | KCNE1KCNQ1 | |
| SCHEMBL7472274 | 0.68 | KCNE1 (0.53) | KCNE1KCNQ1KCNH2THRATHRB | |
| SCHEMBL6935075 | 0.67 | KCNE1 (0.78) | KCNE1KCNQ1KCNH2THRATHRB | |
| SCHEMBL6932248 | 0.65 | KCNE1 (1.00) | KCNE1KCNQ1KCNH2 | |
| SCHEMBL26029578 | 0.64 | HRH3 (0.58) | HTR2AHTR2CNPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915087-B1 | Sulfonamide substituted fused five-membered ring compounds, their use as medicaments as well as pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2003-04-02 | — | — | EP | disclosed |
| US-6015822-A | ANTIULCER, ANTIDIARRHEA, AND ANTIARRHYTHMIA AGENTS; CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-01-18 | — | — | US | disclosed |
| EP-0915087-A2 | Sulfonamide substituted fused five-membered ring compounds, their use as medicaments as well as pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-05-12 | — | — | EP | disclosed |