Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 11/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7732583 | 0.85 | OPRM1 (0.38) | SLC6A4SLC6A3SLC6A2OPRM1KDR | |
| SCHEMBL5161138 | 0.84 | OPRM1 (0.42) | SLC6A4SLC6A3SLC6A2OPRM1KDR | |
| SCHEMBL6937006 | 0.81 | MEN1 (0.34) | SLC6A4SLC6A3SLC6A2OPRM1KDR | |
| SCHEMBL5159940 | 0.81 | OPRM1 (0.40) | SLC6A4SLC6A3SLC6A2OPRM1KDR | |
| SCHEMBL6939122 | 0.79 | TACR1 (0.35) | SLC6A4SLC6A3SLC6A2OPRM1KDR | |
| SCHEMBL6938734 | 0.79 | SLC6A3 (0.46) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL6941375 | 0.77 | OPRM1 (0.41) | SLC6A4SLC6A3SLC6A2OPRM1KDR | |
| SCHEMBL6938750 | 0.77 | OPRM1 (0.40) | SLC6A4SLC6A3SLC6A2OPRM1KDR | |
| SCHEMBL5163165 | 0.77 | OPRM1 (0.44) | SLC6A4SLC6A3SLC6A2OPRM1KDR | |
| SCHEMBL6937411 | 0.77 | OPRM1 (0.56) | SLC6A4SLC6A3SLC6A2OPRM1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |