Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 14/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 12/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 10/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939842 | 0.92 | MEN1 (0.37) | DPP4DPP9DPP7DPP8OPRL1 | |
| SCHEMBL5164050 | 0.89 | CCR5 (0.38) | OPRL1CCR5 | |
| SCHEMBL6937410 | 0.88 | HSD11B1 (0.37) | OPRL1CCR5 | |
| SCHEMBL5163369 | 0.85 | CCR5 (0.38) | CCR5 | |
| SCHEMBL5845135 | 0.84 | CCR5 (0.41) | OPRL1CCR5 | |
| SCHEMBL6936254 | 0.84 | C3AR1 (0.37) | OPRL1CCR5 | |
| SCHEMBL5160201 | 0.84 | CCR5 (0.41) | OPRL1TACR1CCR5 | |
| SCHEMBL5163081 | 0.84 | OPRL1 (0.35) | OPRL1TACR1CCR5 | |
| Hydrochloric Acid SCHEMBL5846901 | 0.83 | CCR5 (0.40) | OPRL1CCR5 | |
| SCHEMBL5158039 | 0.83 | MEN1 (0.40) | OPRL1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |