Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15688602 | 0.85 | L3MBTL1 (0.44) | L3MBTL1TNKSNUDT1HCRTR2HCRTR1 | |
| SCHEMBL21863368 | 0.80 | L3MBTL1 (0.43) | L3MBTL1TNKSNUDT1HCRTR2HCRTR1 | |
| SCHEMBL25095788 | 0.77 | PIK3R1 (0.35) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL9080834 | 0.77 | NUDT1 (0.55) | L3MBTL1TNKSNUDT1ALDH1A1HPGD | |
| SCHEMBL2179459 | 0.77 | L3MBTL1 (0.41) | L3MBTL1TNKSNUDT1HCRTR2ALDH1A1 | |
| SCHEMBL15687846 | 0.76 | L3MBTL1 (0.47) | L3MBTL1TNKSNUDT1HCRTR2HCRTR1 | |
| Bromide SCHEMBL17873904 | 0.76 | L3MBTL1 (0.40) | L3MBTL1TNKSNUDT1ALDH1A1HPGD | |
| SCHEMBL19554927 | 0.75 | MGLL (0.38) | L3MBTL1HCRTR2HCRTR1ALDH1A1 | |
| SCHEMBL21848969 | 0.74 | L3MBTL1 (0.39) | L3MBTL1TNKSNUDT1HCRTR2 | |
| SCHEMBL21848955 | 0.74 | L3MBTL1 (0.39) | L3MBTL1TNKSNUDT1HCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2917219-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | Pfizer Inc. (US) | 2015-09-16 | — | — | EP | disclosed |
| WO-2014072881-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2014-05-15 | — | — | WO | disclosed |
| WO-2011110545-A1 | IMIDAZO [1, 2 -A] PYRAZINE DERIVATIVES AND THEIR USE FOR THE PREVENTION OR TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS AND DISEASES | JANSSEN PHARMACEUTICA NV (BE) | 2011-09-15 | — | — | WO | disclosed |