Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 10/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | GLA | P06280 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9620827 | 0.84 | KDM4E (0.61) | APPNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL13806222 | 0.84 | ALDH1A1 (0.56) | APPNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL9620754 | 0.84 | ALDH1A1 (0.56) | APPNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL143850 | 0.84 | ALDH1A1 (0.59) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL1983852 | 0.83 | CYP3A4 (0.63) | APPNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL8014076 | 0.81 | TNF (0.57) | APPNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL8010166 | 0.80 | ALDH1A1 (0.51) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL9620871 | 0.80 | DYRK1A (0.53) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL9620538 | 0.77 | DYRK1A (0.54) | APPNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL12422442 | 0.77 | APP (0.58) | APPRAB9AGAAALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334091-A2 | THIOFLAVIN DERIVATIVES AND THEIR USE IN DIAGNOSIS AND THERAPY OF ALZHEIMER'S DISEASE | UNIVERSITY OF PITTSBURGH (US) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002016333-A2 | THIOFLAVIN DERIVATIVES AND THEIR USE IN DIAGNOSIS AND THERAPHY OF ALZHEIMER'S DISEASE | UNIVERSITY OF PITTSBURGH (US) | 2002-02-28 | — | — | WO | disclosed |