Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | RARA | P10276 | 1/20 | 0.49 |
| ▸ | RARB | P10826 | 1/20 | 0.49 |
| ▸ | RARG | P13631 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9620538 | 0.90 | DYRK1A (0.54) | DYRK1ADUSP3ALDH1A1TDP1CYP3A4 | |
| SCHEMBL9620838 | 0.87 | RARA (0.47) | DYRK1ADUSP3ALDH1A1TDP1RARA | |
| SCHEMBL143850 | 0.86 | ALDH1A1 (0.59) | DYRK1ADUSP3ALDH1A1TDP1CYP3A4 | |
| SCHEMBL13806222 | 0.83 | ALDH1A1 (0.56) | DYRK1ADUSP3ALDH1A1TDP1CYP3A4 | |
| SCHEMBL9620754 | 0.83 | ALDH1A1 (0.56) | DYRK1ADUSP3ALDH1A1TDP1CYP3A4 | |
| SCHEMBL9620827 | 0.83 | KDM4E (0.61) | DYRK1ADUSP3ALDH1A1TDP1CYP3A4 | |
| SCHEMBL1983852 | 0.82 | CYP3A4 (0.63) | DYRK1AALDH1A1TDP1CYP3A4MAPT | |
| SCHEMBL9620790 | 0.80 | APP (0.63) | DYRK1AALDH1A1TDP1RARARARB | |
| SCHEMBL1043301 | 0.80 | DYRK1A (0.61) | DYRK1ADUSP3ALDH1A1TDP1CYP3A4 | |
| SCHEMBL8014076 | 0.80 | TNF (0.57) | DYRK1ADUSP3ALDH1A1TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0306708-B1 | NOVEL BENZOTHIAZOLE AND ANTIRHEUMATIC AGENT COMPRISING IT AS AN ACTIVE INGREDIENT | KANEBO, LTD. (JP) | 1992-01-08 | — | — | EP | disclosed |
| US-4910211-A | Containing a phenyl substituted in position 2 and an ester in position 4 | KANEBO LTD. (JP) | 1990-03-20 | — | — | US | disclosed |
| EP-0306708-A1 | Novel benzothiazole and antirheumatic agent comprising it as an active ingredient | KANEBO, LTD. (JP) | 1989-03-15 | — | — | EP | disclosed |