Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | METAP2 | P50579 | 5/20 | 0.39 |
| ▸ | METAP1 | P53582 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6485344 | 0.79 | METAP2 (0.61) | ALDH1A1METAP2METAP1MEN1KMT2A | |
| SCHEMBL6485337 | 0.79 | METAP2 (0.61) | ALDH1A1METAP2METAP1MEN1KMT2A | |
| SCHEMBL10768946 | 0.70 | ALDH1A1 (0.70) | ALDH1A1HPGDRXFP1PARP1S1PR1 | |
| SCHEMBL6562801 | 0.69 | METAP2 (0.52) | METAP2METAP1EPHX2SLC6A2SLC6A4 | |
| SCHEMBL7319788 | 0.69 | METAP2 (0.62) | METAP2METAP1 | |
| SCHEMBL6564599 | 0.69 | METAP2 (0.64) | METAP2METAP1EPHX2SLC6A2SLC6A4 | |
| SCHEMBL14996258 | 0.68 | ALDH1A1 (0.51) | ALDH1A1HPGDMEN1POLBKMT2A | |
| SCHEMBL15107648 | 0.67 | OPRM1 (0.45) | ALDH1A1EPHX2 | |
| SCHEMBL15107641 | 0.67 | OPRM1 (0.45) | ALDH1A1EPHX2 | |
| SCHEMBL11779692 | 0.66 | HPGD (0.64) | ALDH1A1HPGDRXFP1PARP1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2003-01-08 | — | — | EP | claimed |
| WO-2001079157-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-25 | — | — | WO | claimed |