Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | TACR2 | P21452 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934468 | 0.90 | SLC6A3 (0.42) | SLC6A3SLC6A4SLC6A2CYP3A4CYP2D6 | |
| SCHEMBL5158078 | 0.87 | OPRM1 (0.40) | OPRM1OPRL1 | |
| SCHEMBL6680122 | 0.84 | SLC6A2 (0.42) | SLC6A4SLC6A2OPRM1OPRL1 | |
| SCHEMBL6681587 | 0.84 | SLC6A4 (0.41) | SLC6A3SLC6A4SLC6A2OPRM1CCR5 | |
| SCHEMBL6676441 | 0.82 | SLC6A2 (0.45) | SLC6A3SLC6A4SLC6A2OPRM1OPRL1 | |
| SCHEMBL6940376 | 0.82 | SLC6A4 (0.36) | SLC6A3SLC6A4SLC6A2OPRM1OPRL1 | |
| SCHEMBL5159886 | 0.81 | OPRM1 (0.42) | OPRM1OPRL1 | |
| SCHEMBL6677382 | 0.80 | CCR5 (0.37) | SLC6A4SLC6A2CCR5TACR1 | |
| Hydrochloric Acid SCHEMBL7737764 | 0.80 | OPRM1 (0.41) | OPRM1OPRL1 | |
| SCHEMBL6675795 | 0.79 | OPRM1 (0.38) | OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |