Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940523 | 0.85 | TGFBR1 (0.31) | — | |
| SCHEMBL6942510 | 0.73 | ADAM17 (0.36) | ADAM17CTSCGRIK1GRIK2MAPT | |
| SCHEMBL6940940 | 0.72 | ADAM17 (0.35) | ADAM17CTSCGRIK1GRIK2MAPT | |
| SCHEMBL6942646 | 0.70 | ADAM17 (0.40) | CYP1B1ADAM17CTSCGRIK1GRIK2 | |
| SCHEMBL6940907 | 0.69 | ADAM17 (0.33) | ADAM17CTSCMAPTMMP1MMP2 | |
| SCHEMBL6942799 | 0.69 | ADAM17 (0.34) | ADAM17CTSCMAPT | |
| SCHEMBL6944604 | 0.68 | ADAM17 (0.36) | ADAM17CTSCGRIK1GRIK2MMP1 | |
| SCHEMBL6989494 | 0.68 | ADAM17 (0.31) | ADAM17CTSCGRIK1GRIK2 | |
| SCHEMBL6939564 | 0.68 | ADAM17 (0.40) | ADAM17CTSCGRIK1GRIK2MAPT | |
| SCHEMBL6943958 | 0.67 | ADAM17 (0.34) | ADAM17CTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |