Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940907 | 0.90 | ADAM17 (0.33) | ADAM17CTSCLMNAMEN1MAPT | |
| SCHEMBL6940940 | 0.90 | ADAM17 (0.35) | ADAM17CTSCLMNAL3MBTL1MEN1 | |
| SCHEMBL6942205 | 0.86 | TGFBR1 (0.32) | — | |
| SCHEMBL6943008 | 0.81 | NAMPT (0.34) | — | |
| SCHEMBL6943182 | 0.81 | CTSC (0.34) | ADAM17CTSCLMNAL3MBTL1MEN1 | |
| SCHEMBL6985696 | 0.81 | CTSC (0.35) | ADAM17CTSCLMNAL3MBTL1MEN1 | |
| SCHEMBL6944737 | 0.80 | MMP9 (0.36) | MAPTSMN1; SMN2 | |
| SCHEMBL6943055 | 0.80 | PIN1 (0.34) | ADAM17CTSCLMNAL3MBTL1MEN1 | |
| SCHEMBL7940341 | 0.79 | F10 (0.32) | LMNAMAPTHTTKMT2A | |
| SCHEMBL6940117 | 0.79 | GRIK1 (0.35) | LMNAMEN1MAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |