SCHEMBL6940199

SCHEMBL6940199

Cc1cc2c(cc1C)CC(c1cc(C(C)(C)C)cc(C(C)(C)C)c1)=C2

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
RXRB P28702 3/20 0.33
POLB P06746 1/20 0.33
KDM4E B2RXH2 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
GABRA1 P14867 1/20 0.31
GABRB2 P47870 1/20 0.31
RXRA P19793 2/20 0.31
RXRG P48443 1/20 0.30
HTR1D P28221 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28015474 0.85 TSHR (0.35) KDM4EMAPTHTR1D
SCHEMBL6940536 0.80 CYP11B1 (0.37) RXRBKDM4EGAAMAPTGABRA1
SCHEMBL6940332 0.80 CYP11B1 (0.35) RXRBKDM4EGAAMAPTRXRA
SCHEMBL28835981 0.79 CYP11B1 (0.31)
SCHEMBL6938203 0.77 RXRA (0.33) RXRBRXRA
SCHEMBL29897870 0.77 CYP11B1 (0.47) RXRBRXRARXRG
SCHEMBL6280690 0.77 CYP11B1 (0.47) RXRBRXRARXRG
SCHEMBL6942040 0.74 CYP11B1 (0.36) KDM4EGAAMAPT
SCHEMBL6939426 0.74 RXRB (0.39) RXRBRXRARXRG
SCHEMBL6939165 0.74 CYP11B1 (0.33) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6479424-B1 FOR PRODUCING OLEFIN POLYMERS AND ESPECIALLY ELASTOMERIC PROPYLENE POLYMERS BP CORPORATION NORTH AMERICA INC. 2002-11-12 US claimed
EP-1157047-B1 LIGANDS AND CATALYSTS FOR PRODUCING ELASTOMERIC PROPYLENE POLYMERS BP CORP NORTH AMERICA INC (US) 2003-04-23 EP disclosed
US-6479424-B1 FOR PRODUCING OLEFIN POLYMERS AND ESPECIALLY ELASTOMERIC PROPYLENE POLYMERS BP CORPORATION NORTH AMERICA INC. 2002-11-12 US disclosed
EP-1157047-A1 LIGANDS AND CATALYSTS FOR PRODUCING ELASTOMERIC PROPYLENE POLYMERS BP Corporation North America Inc. (US) 2001-11-28 EP disclosed
WO-2000035975-A1 LIGANDS AND CATALYSTS FOR PRODUCING ELASTOMERIC PROPYLENE POLYMERS BP CORPORATION NORTH AMERICA INC. (US) 2000-06-22 WO disclosed