Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.56 |
| ▸ | MMP1 | P03956 | 9/20 | 0.56 |
| ▸ | MMP3 | P08254 | 7/20 | 0.56 |
| ▸ | MMP9 | P14780 | 6/20 | 0.56 |
| ▸ | MMP8 | P22894 | 5/20 | 0.56 |
| ▸ | MMP13 | P45452 | 4/20 | 0.56 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.38 |
| ▸ | MMP14 | P50281 | 4/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | MMP7 | P09237 | 3/20 | 0.37 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.37 |
| ▸ | FCER2 | P06734 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947989 | 0.86 | MMP1 (0.46) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL6945858 | 0.82 | ADAM17 (0.57) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL6941765 | 0.81 | ADAM17 (0.52) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL6939991 | 0.80 | MMP1 (0.42) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL6940945 | 0.80 | ADAM17 (0.75) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL7076170 | 0.78 | MMP1 (0.49) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL6940214 | 0.78 | ADAM17 (0.48) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL6939949 | 0.77 | ADAM17 (0.47) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL6945656 | 0.76 | ADAM17 (0.71) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL7280170 | 0.75 | MMP2 (0.60) | MMP2MMP1MMP3MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |