Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.58 |
| ▸ | FCER2 | P06734 | 3/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 4/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947541 | 0.82 | ADAM17 (0.41) | ADAM17FCER2PSMB5PSMB8TAS1R3 | |
| SCHEMBL6942387 | 0.81 | ADAM17 (0.71) | ADAM17FCER2MMP2MMP1MMP8 | |
| SCHEMBL6942613 | 0.75 | ADAM17 (0.68) | ADAM17FCER2MMP2MMP1MMP8 | |
| SCHEMBL3500092 | 0.74 | ADAM17 (1.00) | ADAM17FCER2MMP2MMP1MMP8 | |
| SCHEMBL13274076 | 0.74 | ADAM17 (1.00) | ADAM17FCER2MMP2MMP1MMP8 | |
| SCHEMBL4481744 | 0.74 | ADAM17 (1.00) | ADAM17FCER2MMP2MMP1MMP8 | |
| SCHEMBL6813847 | 0.74 | ADAM17 (1.00) | ADAM17FCER2MMP2MMP1MMP8 | |
| SCHEMBL6813844 | 0.74 | ADAM17 (1.00) | ADAM17FCER2MMP2MMP1MMP8 | |
| SCHEMBL6945579 | 0.74 | ADAM17 (0.62) | ADAM17MMP2MMP1MMP8MMP13 | |
| SCHEMBL6941952 | 0.73 | ADAM17 (0.65) | ADAM17MMP2MMP1MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |