SCHEMBL6940410

SCHEMBL6940410

Cn1c(Cl)c(-c2cc(Oc3cccnc3)c(Cl)cc2F)c(Cl)c1C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.36
ALDH1A1 P00352 1/20 0.34
PPARD Q03181 1/20 0.33
LMNA P02545 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
FFAR4 Q5NUL3 2/20 0.33
CYP19A1 P11511 2/20 0.32
BRD4 O60885 2/20 0.32
HSD11B1 P28845 1/20 0.31
FEN1 P39748 1/20 0.31
MALT1 Q9UDY8 1/20 0.31
P2RX7 Q99572 1/20 0.31
SCN9A Q15858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6938757 0.75 CNR2 (0.32) ALDH1A1
SCHEMBL6937717 0.75 PPOX (0.35) LMNATDP1
SCHEMBL6937897 0.75 ALDH1A1 (0.31) SMN1; SMN2ALDH1A1
SCHEMBL6932393 0.75 HSD11B1 (0.32) HSD11B1SCN9A
SCHEMBL7721194 0.74 PDK2 (0.39) SMN1; SMN2ALDH1A1LMNA
SCHEMBL7703288 0.73 BACE1 (0.35) ALDH1A1LMNA
SCHEMBL6938725 0.73
SCHEMBL7693700 0.72
SCHEMBL6935033 0.72
SCHEMBL6935022 0.72 PPOX (0.41) SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1061072-B1 Pyrrolic compounds with a high herbicidal activity and their agronomic use ISAGRO RICERCA SRL (IT) 2003-05-14 EP disclosed
US-6391827-B1 CONTROLLING WEEDS ISAGRO RICERCA S.R.L. (IT) 2002-05-21 US disclosed
EP-1061072-A1 Pyrrolic compounds with a high herbicidal activity and their agronomic use ISAGRO RICERCA S.r.l. (IT) 2000-12-20 EP disclosed