Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.34 |
| ▸ | ESR1 | P03372 | 3/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6575923 | 0.73 | ALDH1A1 (0.46) | ALDH1A1CYP3A4MAPK1HIF1ATP53 | |
| SCHEMBL9066522 | 0.72 | KCNH2 (0.32) | TP53 | |
| SCHEMBL311787 | 0.70 | — | — | |
| Chloromethane SCHEMBL27694215 | 0.70 | TAAR1 (0.39) | TAAR1SLC6A2CYP3A4LMNACYP2D6 | |
| Fluoride SCHEMBL27930946 | 0.69 | TP53 (0.39) | ESR1ESR2ALDH1A1LMNAMAPK1 | |
| SCHEMBL28458487 | 0.67 | MAPK1 (0.31) | MAPK1 | |
| SCHEMBL22730225 | 0.67 | TAAR1 (0.41) | TAAR1ESR1ESR2ALDH1A1CYP3A4 | |
| SCHEMBL3682860 | 0.67 | TP53 (0.38) | ALDH1A1CYP3A4LMNAMAPK1TP53 | |
| SCHEMBL10523373 | 0.67 | TP53 (0.32) | TAAR1SLC6A2ALDH1A1LMNAMAPK1 | |
| SCHEMBL10398619 | 0.66 | TAAR1 (0.36) | TAAR1ESR1ESR2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971889-B1 | PROCESS FOR SYNTHESIZING CARBAPENEM INTERMEDIATES | MERCK & CO INC (US) | 2003-08-13 | — | — | EP | claimed |
| EP-1015452-B1 | OPTIONALLY PROTECTED 3-HYDROXYMETHYL CARBAPENEMS AND SYNTHESIS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | claimed |
| US-6346617-B1 | ANTIBIOTICS FORMED BY MULTISTAGE REACTION WITH CATALYTIC OXIDATION AND CONDENSATION | MERCK & CO., INC. | 2002-02-12 | — | — | US | claimed |
| EP-1015452-A4 | OPTIONALLY PROTECTED 3-HYDROXYMETHYL CARBAPENEMS AND SYNTHESIS | MERCK & CO INC (US) | 2001-07-11 | — | — | EP | claimed |
| EP-0971889-A4 | PROCESS FOR SYNTHESIZING CARBAPENEM INTERMEDIATES | MERCK & CO INC (US) | 2001-01-17 | — | — | EP | claimed |
| EP-1015452-A1 | OPTIONALLY PROTECTED 3-HYDROXYMETHYL CARBAPENEMS AND SYNTHESIS | Merck & Co., Inc. (US) | 2000-07-05 | — | — | EP | claimed |
| US-6080854-A | Process for synthesizing carbapenem intermediates | MERCK & CO., INC. (US) | 2000-06-27 | — | — | US | claimed |
| EP-0971889-A1 | PROCESS FOR SYNTHESIZING CARBAPENEM INTERMEDIATES | Merck & Co., Inc. (US) | 2000-01-19 | — | — | EP | claimed |
| US-5973142-A | Process for synthesizing carbapenem intermediates | MERCK & CO., INC. | 1999-10-26 | — | — | US | claimed |
| WO-1999010348-A1 | OPTIONALLY PROTECTED 3-HYDROXYMETHYL CARBAPENEMS AND SYNTHESIS | MERCK & CO., INC. (US) | 1999-03-04 | — | — | WO | claimed |
| WO-1998031666-A1 | PROCESS FOR SYNTHESIZING CARBAPENEM INTERMEDIATES | MERCK & CO., INC. (US) | 1998-07-23 | — | — | WO | claimed |
| US-10253038-B2 | Fusicoccane derivatives and methods | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2019-04-09 | — | — | US | disclosed |
| US-20180312518-A1 | Fusicoccane Derivatives and Methods | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2018-11-01 | — | — | US | disclosed |
| EP-0971889-B1 | PROCESS FOR SYNTHESIZING CARBAPENEM INTERMEDIATES | MERCK & CO INC (US) | 2003-08-13 | — | — | EP | disclosed |
| EP-1015452-B1 | OPTIONALLY PROTECTED 3-HYDROXYMETHYL CARBAPENEMS AND SYNTHESIS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-0126709-B1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE AZETIDINONES | CIBA-GEIGY AG (CH) | 1991-04-03 | — | — | EP | disclosed |
| EP-0167155-B1 | BETA-LACTAM COMPOUND AND PREPARING THEREOF | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-03-08 | — | — | EP | disclosed |
| US-4791198-A | CHEMICAL INTERMEDIATES FOR THIENAMYCINS | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1988-12-13 | — | — | US | disclosed |
| EP-0167155-A1 | beta-Lactam compound and preparing thereof | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1986-01-08 | — | — | EP | disclosed |
| EP-0126709-A1 | Process for the preparation of optically active azetidinones | CIBA-GEIGY AG (CH) | 1984-11-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312518-A1 | Fusicoccane Derivatives and Methods | FGB, BLVRB, GNE | TAAR1 3999/4885SLC6A2 4823/4885RIPK1 990/4885 |
| US-10253038-B2 | Fusicoccane derivatives and methods | FGB, BLVRB, GNE | TAAR1 3999/4885SLC6A2 4823/4885RIPK1 990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.