SCHEMBL6941388

SCHEMBL6941388

CN(C)Cc1c[nH]c2ccc(Cn3cnnc3)cc12

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 13/20 0.58
HTR2C P28335 11/20 0.58
HTR1D P28221 3/20 0.52
HTR1B P28222 3/20 0.52
ADRA2C P18825 1/20 0.52
HTR2A P28223 1/20 0.52
HRH1 P35367 1/20 0.52
HTR2B P41595 1/20 0.52
KDM4E B2RXH2 1/20 0.49
MEN1 O00255 1/20 0.49
ALDH1A1 P00352 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
TSHR P16473 1/20 0.49
CYP2C19 P33261 1/20 0.49
KMT2A Q03164 1/20 0.49
HSD17B10 Q99714 1/20 0.49
HTR5A P47898 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6941530 0.87 HTR1A (0.75) HTR1AHTR2CHTR1DHTR1BADRA2C
SCHEMBL6939216 0.85 HTR1A (0.65) HTR1AHTR2CHTR1DHTR1BADRA2C
SCHEMBL6945754 0.85 HTR1A (0.79) HTR1AHTR2CHTR1DHTR1BADRA2C
SCHEMBL8696560 0.82 MPO (0.51) HTR1AHTR2CHTR1DHTR1BADRA2C
SCHEMBL6946024 0.81 HTR1A (0.60) HTR1AHTR2CHTR1DHTR1BADRA2C
SCHEMBL6943909 0.80 HTR1A (0.79) HTR1AHTR2CHTR1DHTR1BADRA2C
SCHEMBL7481572 0.80 HTR2C (0.55) HTR1AHTR2CHTR1DHTR1BADRA2C
SCHEMBL27372909 0.79 HTR1A (0.49) HTR1AHTR2CHTR1DHTR1BADRA2C
SCHEMBL3029512 0.79 HTR1A (0.73) HTR1AHTR2CHTR1DHTR1BHTR2A
SCHEMBL6943928 0.78 HTR1D (0.76) HTR1DHTR1BKDM4EMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0925302-B1 PALLADIUM CATALYZED INDOLIZATION MERCK & CO INC (US) 2002-11-20 EP claimed
CN-1322725-A Indole derivant MERCK & CO INC (US) 2001-11-21 CN claimed
CN-1228094-A Palladium catalyzed indolization MERCK & CO INC (US) 1999-09-08 CN claimed
EP-0925302-A1 PALLADIUM CATALYZED INDOLIZATION Merck & Co., Inc. (US) 1999-06-30 EP claimed
WO-1998006725-A1 PALLADIUM CATALYZED INDOLIZATION MERCK & CO., INC. (US) 1998-02-19 WO claimed
CN-1152920-A Palladium-Catalyzed Ring Closure of Triazolyl Tryptamine MERCK & CO INC (US) 1997-06-25 CN claimed
US-5567824-A CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR MERCK & CO., INC. (US) 1996-10-22 US claimed
CN-1157390-C Indole derivant 2004-07-14 CN disclosed
EP-0763032-B1 PALLADIUM CATALYZED RING CLOSURE OF TRIAZOLYL TRYPTAMINE MERCK & CO INC (US) 2003-10-15 EP disclosed
EP-0925302-B1 PALLADIUM CATALYZED INDOLIZATION MERCK & CO INC (US) 2002-11-20 EP disclosed
CN-1084751-C Palladium catalyzed indolization MERCK & CO INC (US) 2002-05-15 CN disclosed
CN-1077104-C Palladium-Catalyzed Ring Closure of Triazolyl Tryptamine MERCK & CO INC (US) 2002-01-02 CN disclosed
CN-1322725-A Indole derivant MERCK & CO INC (US) 2001-11-21 CN disclosed
CN-1228094-A Palladium catalyzed indolization MERCK & CO INC (US) 1999-09-08 CN disclosed
US-5808064-A HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE MERCK & CO., INC. (US) 1998-09-15 US disclosed
CN-1152920-A Palladium-Catalyzed Ring Closure of Triazolyl Tryptamine MERCK & CO INC (US) 1997-06-25 CN disclosed
US-5567824-A CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR MERCK & CO., INC. (US) 1996-10-22 US disclosed