Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.55 |
| ▸ | HTR1A | P08908 | 10/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 8/20 | 0.47 |
| ▸ | HTR1B | P28222 | 8/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480332 | 0.85 | HTR2C (0.73) | HTR2CHTR1ACYP2D6HTR1DHTR1B | |
| SCHEMBL8696560 | 0.83 | MPO (0.51) | HTR2CHTR1AHTR1DHTR1BADRA2C | |
| SCHEMBL6941530 | 0.83 | HTR1A (0.75) | HTR2CHTR1AHTR1DHTR1BADRA2C | |
| SCHEMBL6946024 | 0.82 | HTR1A (0.60) | HTR2CHTR1AHTR1DHTR1BADRA2C | |
| SCHEMBL6939216 | 0.81 | HTR1A (0.65) | HTR2CHTR1AHTR1DHTR1BADRA2C | |
| SCHEMBL7476241 | 0.80 | HTR1A (0.52) | HTR2CHTR1ACYP2D6HTR1DHTR1B | |
| SCHEMBL6941388 | 0.80 | HTR1A (0.58) | HTR2CHTR1ACYP2D6HTR1DHTR1B | |
| SCHEMBL4344147 | 0.80 | HTR1D (0.73) | HTR2CHTR1ACYP2D6HTR1DHTR1B | |
| SCHEMBL16675461 | 0.79 | HTR2C (0.68) | HTR2CHTR1ACYP2D6HTR1DHTR1B | |
| SCHEMBL7480727 | 0.78 | HTR1D (0.70) | HTR2CHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | claimed |
| CN-1322725-A | Indole derivant | MERCK & CO INC (US) | 2001-11-21 | — | — | CN | claimed |
| CN-1228094-A | Palladium catalyzed indolization | MERCK & CO INC (US) | 1999-09-08 | — | — | CN | claimed |
| CN-1152920-A | Palladium-Catalyzed Ring Closure of Triazolyl Tryptamine | MERCK & CO INC (US) | 1997-06-25 | — | — | CN | claimed |
| CN-1157390-C | Indole derivant | — | 2004-07-14 | — | — | CN | disclosed |
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| CN-1084751-C | Palladium catalyzed indolization | MERCK & CO INC (US) | 2002-05-15 | — | — | CN | disclosed |
| CN-1077104-C | Palladium-Catalyzed Ring Closure of Triazolyl Tryptamine | MERCK & CO INC (US) | 2002-01-02 | — | — | CN | disclosed |
| CN-1322725-A | Indole derivant | MERCK & CO INC (US) | 2001-11-21 | — | — | CN | disclosed |
| CN-1228094-A | Palladium catalyzed indolization | MERCK & CO INC (US) | 1999-09-08 | — | — | CN | disclosed |
| CN-1152920-A | Palladium-Catalyzed Ring Closure of Triazolyl Tryptamine | MERCK & CO INC (US) | 1997-06-25 | — | — | CN | disclosed |