Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7937957 | 0.90 | P2RX3 (0.33) | P2RX3TGFBR1 | |
| SCHEMBL7928806 | 0.86 | P2RX3 (0.34) | P2RX3TGFBR1LNPEPALDH1A1GAA | |
| SCHEMBL7940275 | 0.83 | CCNA2 (0.31) | P2RX3LNPEPCCNA2CDK2CCNA1 | |
| SCHEMBL6941960 | 0.79 | ADAM17 (0.33) | P2RX3TGFBR1ALDH1A1GAAMGLL | |
| SCHEMBL8111706 | 0.79 | ADAM17 (0.33) | P2RX3TGFBR1ALDH1A1GAAMGLL | |
| SCHEMBL6942209 | 0.79 | ADAM17 (0.33) | P2RX3TGFBR1ALDH1A1GAAMGLL | |
| SCHEMBL6943556 | 0.79 | ADAM17 (0.33) | P2RX3TGFBR1ALDH1A1GAAMGLL | |
| SCHEMBL6940928 | 0.77 | ALDH1A1 (0.35) | LNPEPALDH1A1GAACTSK | |
| SCHEMBL6943373 | 0.77 | ADAM17 (0.33) | P2RX3TGFBR1ALDH1A1GAAMGLL | |
| SCHEMBL6937784 | 0.76 | ADAM17 (0.33) | P2RX3TGFBR1ALDH1A1GAAMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |