Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.33 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936762 | 0.85 | SLC6A9 (0.39) | SLC6A9OPRL1LMNASLC18A3OPRM1 | |
| SCHEMBL6938861 | 0.85 | GRIN2B (0.39) | SLC6A9OPRL1TRPA1CACNA1G | |
| Hydrochloric Acid SCHEMBL7741182 | 0.84 | OPRL1 (0.39) | SLC6A9OPRL1LMNASLC18A3OPRM1 | |
| SCHEMBL5163369 | 0.83 | CCR5 (0.38) | SLC6A9TRPA1CACNA1G | |
| SCHEMBL6936116 | 0.81 | SLC6A9 (0.39) | SLC6A9OPRL1LMNASLC18A3OPRM1 | |
| SCHEMBL6940299 | 0.81 | SLC6A2 (0.44) | SLC6A9OPRL1OPRM1OPRK1TSHR | |
| SCHEMBL6936962 | 0.81 | SLC6A4 (0.40) | SLC6A9OPRL1 | |
| SCHEMBL6936749 | 0.81 | OPRM1 (0.37) | SLC6A9OPRL1LMNASLC18A3OPRM1 | |
| SCHEMBL5160201 | 0.80 | CCR5 (0.41) | OPRL1STSOPRM1TRPA1OPRK1 | |
| SCHEMBL5163081 | 0.80 | OPRL1 (0.35) | SLC6A9OPRL1LMNAOPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |