Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 3/20 | 0.44 |
| ▸ | MMP3 | P08254 | 3/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 4/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 3/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943313 | 0.90 | CTSK (0.41) | MMP1MMP3MMP9CTSKCTSS | |
| SCHEMBL6943309 | 0.90 | CTSK (0.41) | MMP1MMP3MMP9CTSKCTSS | |
| SCHEMBL6941577 | 0.85 | MMP1 (0.50) | MMP1MMP3MMP9MMP13MMP8 | |
| SCHEMBL7827850 | 0.83 | MMP1 (0.46) | MMP1MMP3MMP9CTSKCTSS | |
| SCHEMBL7853167 | 0.83 | MMP1 (0.46) | MMP1MMP3MMP9CTSKCTSS | |
| SCHEMBL7836454 | 0.83 | MMP1 (0.46) | MMP1MMP3MMP9CTSKCTSS | |
| SCHEMBL7853162 | 0.83 | MMP1 (0.46) | MMP1MMP3MMP9CTSKCTSS | |
| SCHEMBL6943292 | 0.81 | MMP3 (0.45) | MMP1MMP3MMP9CTSKCTSS | |
| SCHEMBL6659520 | 0.81 | MMP3 (0.45) | MMP1MMP3MMP9CTSKCTSS | |
| SCHEMBL6943287 | 0.81 | MMP3 (0.45) | MMP1MMP3MMP9CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |