Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Propofol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.49 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.49 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.49 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.49 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.49 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.49 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.49 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.49 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.49 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.49 |
| ▸ | GSR | P00390 | 1/20 | 0.57 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propofol SCHEMBL6945747 | 0.82 | CYP1A2 (0.55) | GSRFAAHCA1CA2LMNA | |
| Propofol SCHEMBL28482984 | 0.80 | GABRA1 (0.57) | FAAHCA1CA2LMNACYP1A2 | |
| Lysine SCHEMBL27602037 | 0.80 | GSR (0.77) | GSRCYP1A2CYP3A4TSHRBLM | |
| Lysine SCHEMBL28159830 | 0.80 | GSR (0.77) | GSRCYP1A2CYP3A4TSHRBLM | |
| Lysine SCHEMBL28214073 | 0.79 | GSR (0.91) | GSRCYP1A2CYP3A4TSHRPOLB | |
| Propofol SCHEMBL6946977 | 0.79 | GABRA1 (0.55) | FAAHCA1CA2LMNACYP1A2 | |
| Lysine SCHEMBL28249818 | 0.79 | GSR (0.69) | GSRPTGS1POLBKMT2ATDP1 | |
| Lysine SCHEMBL28249816 | 0.79 | GSR (0.69) | GSRPTGS1POLBKMT2ATDP1 | |
| Amphetamine SCHEMBL28843066 | 0.78 | GSR (0.59) | GSRPTGS1SLC6A2THRBPOLB | |
| Amphetamine SCHEMBL578976 | 0.78 | GSR (0.59) | GSRPTGS1SLC6A2THRBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003105817-A1 | NOVEL PARENTERAL COMPOSITION COMPRISING PROPOFOL | FDL, INC. (KR) | 2003-12-24 | — | — | WO | disclosed |