Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKCH | P24723 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844253 | 0.90 | AKR1C3 (0.51) | AKR1C3AKR1C2MEN1KMT2AMAPT | |
| SCHEMBL19934156 | 0.83 | AKR1C3 (0.56) | AKR1C3AKR1C2MAPTIDO1TDO2 | |
| SCHEMBL30567365 | 0.83 | MEN1 (0.56) | AKR1C3AKR1C2MEN1KMT2AMAPT | |
| SCHEMBL7844252 | 0.83 | MEN1 (0.56) | AKR1C3AKR1C2MEN1KMT2AMAPT | |
| SCHEMBL9722931 | 0.80 | CES2 (0.44) | PRKCIHDAC1CLCN2 | |
| SCHEMBL21327632 | 0.79 | AKR1C3 (0.65) | AKR1C3AKR1C2MEN1KMT2AMAPT | |
| SCHEMBL31563092 | 0.77 | AKR1C3 (0.59) | AKR1C3AKR1C2MEN1KMT2AMAPT | |
| SCHEMBL1415570 | 0.77 | MAPT (0.56) | AKR1C3AKR1C2MEN1KMT2APRKD3 | |
| SCHEMBL848085 | 0.76 | AKR1C3 (0.60) | AKR1C3AKR1C2PRKD3MAPTCLCN2 | |
| SCHEMBL6950478 | 0.75 | AKR1C3 (0.50) | AKR1C3AKR1C2MEN1KMT2ACLCN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783505-B1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| US-5869485-A | Pyrrolo 2,3-d!pyrimidines and their use | NOVARTIS FINANCE CORP. (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0783505-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | Novartis AG (CH) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010028-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 1996-04-04 | — | — | WO | disclosed |