Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 3/20 | 0.34 |
| ▸ | MMP7 | P09237 | 3/20 | 0.34 |
| ▸ | MMP12 | P39900 | 3/20 | 0.34 |
| ▸ | MMP13 | P45452 | 3/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.34 |
| ▸ | ACE | P12821 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939936 | 0.93 | ADAM17 (0.56) | ADAM17LMNATSHRCTSCMMP1 | |
| SCHEMBL6940033 | 0.86 | ADAM17 (0.49) | ADAM17CTSCMMP13GRIK1GRIK2 | |
| SCHEMBL6948294 | 0.82 | ADAM17 (0.48) | ADAM17CTSCGRIK1GRIK2MMP2 | |
| SCHEMBL6939612 | 0.79 | ADAM17 (0.58) | ADAM17CTSCMMP1MMP7MMP12 | |
| SCHEMBL6940945 | 0.79 | ADAM17 (0.75) | ADAM17MMP1MMP7MMP12MMP13 | |
| SCHEMBL6944720 | 0.78 | ADAM17 (0.54) | ADAM17CTSCMMP1MMP13GRIK1 | |
| SCHEMBL6942218 | 0.78 | ADAM17 (0.54) | ADAM17MMP1MMP7MMP2MMP3 | |
| SCHEMBL6943824 | 0.76 | ADAM17 (0.55) | ADAM17CTSCMMP1MMP13MMP2 | |
| SCHEMBL6939403 | 0.76 | ADAM17 (0.55) | ADAM17MMP1MMP13MMP2MMP3 | |
| SCHEMBL6945656 | 0.74 | ADAM17 (0.71) | ADAM17MMP1MMP7MMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |