Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.36 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PAM | P19021 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944720 | 0.93 | ADAM17 (0.54) | ADAM17GRIK1GRIK2CTSCHTR2A | |
| SCHEMBL6940033 | 0.84 | ADAM17 (0.49) | ADAM17GRIK1GRIK2CTSCHTT | |
| SCHEMBL6944522 | 0.82 | ADAM17 (0.48) | ADAM17GRIK1GRIK2CTSCHTT | |
| SCHEMBL6939783 | 0.80 | ADAM17 (0.37) | ADAM17CTSC | |
| SCHEMBL6940945 | 0.79 | ADAM17 (0.75) | ADAM17MMP2MMP9 | |
| SCHEMBL6939612 | 0.79 | ADAM17 (0.58) | ADAM17CTSCMMP2MMP9PPARG | |
| SCHEMBL6939936 | 0.78 | ADAM17 (0.56) | ADAM17CTSCHTTCYP1A2MMP2 | |
| SCHEMBL6939403 | 0.76 | ADAM17 (0.55) | ADAM17MMP2MMP9GAA | |
| SCHEMBL6943824 | 0.76 | ADAM17 (0.55) | ADAM17CTSCMMP2MMP9GAA | |
| SCHEMBL6942218 | 0.76 | ADAM17 (0.54) | ADAM17MMP2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |