Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6841756 | 0.82 | MAOB (0.54) | MAOBIDO1ALDH1A1MAPTMEN1 | |
| SCHEMBL28289727 | 0.73 | MAPT (0.35) | IDO1ALDH1A1MAPTMEN1HPGD | |
| SCHEMBL7102655 | 0.73 | MAOB (0.53) | MAOBIDO1ALDH1A1MAPTMEN1 | |
| SCHEMBL15484146 | 0.71 | IDO1 (0.75) | MAOBIDO1ALDH1A1MAPTMEN1 | |
| SCHEMBL6841445 | 0.70 | MAOB (0.47) | MAOBIDO1ALDH1A1MAPTMEN1 | |
| SCHEMBL7098462 | 0.70 | MAOB (0.61) | MAOBIDO1ALDH1A1MAPTMEN1 | |
| SCHEMBL6841201 | 0.68 | ALDH1A1 (0.55) | MAOBALDH1A1MAPTMEN1HPGD | |
| SCHEMBL4341689 | 0.68 | MAOB (0.54) | MAOBIDO1ALDH1A1MAPTMEN1 | |
| SCHEMBL6836479 | 0.67 | MAOB (0.57) | MAOBIDO1ALDH1A1MAPTMEN1 | |
| SCHEMBL5445907 | 0.67 | MAPT (0.75) | MAOBALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360173-A2 | TRISUBSTITUTED CARBOCYCLIC CYCLOPHILIN BINDING COMPOUNDS AND THEIR USE | GUILFORD PHARMACEUTICALS INC. (US) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002059080-A2 | TRISUBSTITUTED CARBOCYCLIC CYCLOPHILIN BINDING COMPOUNDS AND THEIR USE | GUILFORD PHARMACEUTICALS INC. (US) | 2002-08-01 | — | — | WO | disclosed |