Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Eletriptan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B known ✓ | P28222 | 7/20 | 0.95 |
| ▸ | HTR1D known ✓ | P28221 | 6/20 | 0.62 |
| ▸ | HTR1F known ✓ | P30939 | 2/20 | 0.55 |
| ▸ | HTR1A | P08908 | 3/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.95 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.95 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.95 |
| ▸ | DRD1 | P21728 | 1/20 | 0.95 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.95 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.95 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.95 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.95 |
| ▸ | HTR6 | P50406 | 15/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eletriptan SCHEMBL26719 | 0.97 | HTR1B (1.00) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| Eletriptan SCHEMBL29414096 | 0.97 | HTR1B (1.00) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| Eletriptan SCHEMBL10083479 | 0.97 | HTR1B (1.00) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| Eletriptan SCHEMBL798473 | 0.97 | HTR1B (1.00) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| Eletriptan SCHEMBL1556539 | 0.97 | HTR1B (1.00) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| Eletriptan SCHEMBL4233264 | 0.96 | HTR1B (0.98) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| Eletriptan SCHEMBL1068516 | 0.96 | HTR1B (0.98) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| Eletriptan SCHEMBL4431798 | 0.96 | HTR1B (0.98) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| Eletriptan SCHEMBL3713443 | 0.96 | HTR1B (0.98) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| Eletriptan SCHEMBL29984875 | 0.96 | HTR1B (0.98) | HTR1BHTR1ACHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102414198-B | Synthesis of 3- { [ (2R) -1-methylpyrrolidin-2-yl ] methyl } -5- [2- (phenylsulfonyl) ethyl ] -1H-indole | ITALIANA SINT SPA | 2014-11-12 | — | — | CN | disclosed |
| US-8633239-B2 | Process for the preparation of eletriptan | BIOPHORE INDIA PHARMACEUTICALS PRIVATE LIMITED (IN) | 2014-01-21 | — | — | US | disclosed |
| EP-2421853-B1 | SYNTHESIS OF 3-{[(2R)-1-METHYLPYRROLIDIN-2-YL]METHYL}-5-[2-(PHENYLSULFONYL)ETHYL]-1H-INDOLE | ITALIANA SINT SPA (IT) | 2013-07-24 | — | — | EP | disclosed |
| EP-2349998-B1 | A NOVEL PROCESS FOR THE PREPARATION OF ELETRIPTAN | BIOPHORE INDIA PHARMACEUTICALS PVT LTD (IN) | 2013-07-17 | — | — | EP | disclosed |
| US-8426612-B2 | Synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5[2-(phenylsulfonyl)ethyl]-1H-indole | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2013-04-23 | — | — | US | disclosed |
| CN-102414198-A | Synthesis of 3- { [ (2R) -1-methylpyrrolidin-2-yl ] methyl } -5- [2- (phenylsulfonyl) ethyl ] -1H-indole | ITALIANA SINT SPA | 2012-04-11 | — | — | CN | disclosed |
| EP-2421853-A1 | SYNTHESIS OF 3-{[(2R)-1-METHYLPYRROLIDIN-2-YL]METHYL}-5-[2-(PHENYLSULFONYL)ETHYL]-1H-INDOLE | F.I.S. Fabbrica Italiana Sintetici S.p.A. (IT) | 2012-02-29 | — | — | EP | disclosed |
| US-20110207943-A1 | NOVEL PROCESS FOR THE PREPARATION OF ELETRIPTAN | BIOPHORE INDIA PHARMACEUTICALS PRIVATE LIMITED (IN) | 2011-08-25 | — | — | US | disclosed |
| EP-2349998-A2 | A NOVEL PROCESS FOR THE PREPARATION OF ELETRIPTAN | Biophore India Pharmaceuticals Pvt. Ltd. (IN) | 2011-08-03 | — | — | EP | disclosed |
| US-20110166364-A1 | SYNTHESIS OF 3--5-[2-(PHENYLSULFONYL)ETHYL]-1H-INDOLE | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2011-07-07 | — | — | US | disclosed |
| WO-2010121673-A1 | SYNTHESIS OF 3-{[(2R)-1-METHYLPYRROLIDIN-2-YL]METHYL}-5-[2-(PHENYLSULFONYL)ETHYL]-1H-INDOLE | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2010-10-28 | — | — | WO | disclosed |
| WO-2010049952-A2 | A NOVEL PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED INDOLE DERIVATIVES | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) | 2010-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207943-A1 | NOVEL PROCESS FOR THE PREPARATION OF ELETRIPTAN | HTR3C, HTR3A, HTR1A | HTR1B 24/4885HTR1D 13/4885HTR1F 44/4885 |
| US-20110166364-A1 | SYNTHESIS OF 3--5-[2-(PHENYLSULFONYL)ETHYL]-1H-INDOLE | TMPRSS15, PEPD, DPP9 | HTR1B 254/4885HTR1D 137/4885HTR1F 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.