Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944200 | 0.87 | ADAM17 (0.45) | ADAM17TP53ALDH1A1TSHRHPGD | |
| SCHEMBL6939576 | 0.82 | ADAM17 (0.40) | ADAM17ALDH1A1MEN1KMT2A | |
| SCHEMBL6945114 | 0.81 | ADAM17 (0.37) | ADAM17MEN1KMT2AHPGD | |
| SCHEMBL6941639 | 0.80 | MAPT (0.37) | ADAM17KMT2ALMNAHPGDCYP2C9 | |
| SCHEMBL6940045 | 0.79 | KMT2A (0.34) | ADAM17TP53ALDH1A1KMT2ATSHR | |
| SCHEMBL6947989 | 0.77 | MMP1 (0.46) | ADAM17ALDH1A1MEN1KMT2A | |
| SCHEMBL7928755 | 0.72 | PSMB5 (0.46) | ALDH1A1MEN1KMT2A | |
| SCHEMBL6941589 | 0.72 | ADAM17 (0.49) | ADAM17 | |
| SCHEMBL7937102 | 0.71 | MMP2 (0.33) | LMNAHTT | |
| SCHEMBL6941765 | 0.68 | ADAM17 (0.52) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |