Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 12/20 | 0.39 |
| ▸ | MMP1 | P03956 | 10/20 | 0.39 |
| ▸ | MMP8 | P22894 | 9/20 | 0.39 |
| ▸ | MMP13 | P45452 | 4/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 10/20 | 0.37 |
| ▸ | MMP3 | P08254 | 7/20 | 0.34 |
| ▸ | MMP9 | P14780 | 5/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 3/20 | 0.33 |
| ▸ | TNF | P01375 | 2/20 | 0.33 |
| ▸ | MMP20 | O60882 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | MMP10 | P09238 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | MMP15 | P51511 | 1/20 | 0.33 |
| ▸ | MMP16 | P51512 | 1/20 | 0.33 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.33 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940029 | 0.85 | MMP1 (0.36) | MMP2MMP1MMP8MMP13ADAM17 | |
| SCHEMBL6942689 | 0.84 | MMP1 (0.35) | MMP2MMP1MMP8MMP13ADAM17 | |
| SCHEMBL6942202 | 0.84 | ADAM17 (0.32) | MMP2MMP1MMP8MMP13ADAM17 | |
| SCHEMBL6941949 | 0.83 | ADAM17 (0.37) | MMP2MMP1MMP13ADAM17MMP3 | |
| SCHEMBL6938049 | 0.80 | ADAM17 (0.35) | MMP2MMP1MMP8MMP13ADAM17 | |
| SCHEMBL6942520 | 0.79 | ADAM17 (0.41) | MMP2MMP1MMP8MMP13ADAM17 | |
| SCHEMBL6942381 | 0.78 | ADAM17 (0.40) | MMP2MMP1ADAM17MMP3MMP9 | |
| SCHEMBL6943812 | 0.75 | MMP1 (0.34) | MMP2MMP1MMP8MMP13ADAM17 | |
| SCHEMBL6942609 | 0.75 | ADAM17 (0.42) | MMP2MMP1MMP13ADAM17MMP3 | |
| SCHEMBL6942610 | 0.74 | ADAM17 (0.46) | MMP2MMP1MMP8MMP13ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |