Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 15/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 13/20 | 0.34 |
| ▸ | MMP2 | P08253 | 13/20 | 0.34 |
| ▸ | MMP3 | P08254 | 11/20 | 0.34 |
| ▸ | MMP13 | P45452 | 8/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942689 | 0.91 | MMP1 (0.35) | MMP1MMP9MMP14MMP8MMP2 | |
| SCHEMBL6942202 | 0.90 | ADAM17 (0.32) | MMP1MMP8MMP2MMP3MMP13 | |
| SCHEMBL6945575 | 0.85 | MMP2 (0.39) | MMP1MMP9MMP14MMP8MMP2 | |
| SCHEMBL6940360 | 0.76 | — | — | |
| SCHEMBL6946037 | 0.76 | ADAM17 (0.41) | MMP1MMP9MMP14MMP2MMP3 | |
| SCHEMBL6939483 | 0.75 | ADAM17 (0.41) | MMP1MMP9MMP14MMP2MMP3 | |
| SCHEMBL6980958 | 0.74 | MMP1 (0.35) | MMP1MMP9MMP14MMP8MMP2 | |
| SCHEMBL6941949 | 0.73 | ADAM17 (0.37) | MMP1MMP9MMP14MMP2MMP3 | |
| SCHEMBL6943171 | 0.73 | ADAM17 (0.41) | MMP1MMP9MMP14MMP2MMP3 | |
| SCHEMBL6943812 | 0.72 | MMP1 (0.34) | MMP1MMP8MMP2MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |