Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 6/20 | 0.37 |
| ▸ | MMP9 | P14780 | 4/20 | 0.36 |
| ▸ | MMP1 | P03956 | 3/20 | 0.36 |
| ▸ | MMP13 | P45452 | 3/20 | 0.36 |
| ▸ | ANPEP | P15144 | 3/20 | 0.35 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 3/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | FCER2 | P06734 | 1/20 | 0.34 |
| ▸ | LAP3 | P28838 | 1/20 | 0.34 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945575 | 0.83 | MMP2 (0.39) | ADAM17MMP9MMP1MMP13MMP2 | |
| SCHEMBL6945566 | 0.82 | KDM4E (0.33) | MMP9ANPEPLTA4HMMP2LAP3 | |
| SCHEMBL6942381 | 0.79 | ADAM17 (0.40) | ADAM17MMP9MMP1ANPEPLTA4H | |
| SCHEMBL6940240 | 0.77 | ADAM17 (0.37) | ADAM17MMP9MMP1ANPEPLTA4H | |
| SCHEMBL6942609 | 0.76 | ADAM17 (0.42) | ADAM17MMP9MMP1MMP13ANPEP | |
| SCHEMBL6942610 | 0.75 | ADAM17 (0.46) | ADAM17MMP9MMP1MMP13ANPEP | |
| SCHEMBL4481740 | 0.75 | ADAM17 (0.46) | ADAM17MMP9MMP1MMP13ANPEP | |
| SCHEMBL6942520 | 0.75 | ADAM17 (0.41) | ADAM17MMP9MMP1MMP13MMP2 | |
| SCHEMBL7099916 | 0.73 | MMP8 (0.39) | ADAM17MMP1MMP13ANPEPMMP2 | |
| SCHEMBL7100104 | 0.73 | ANPEP (0.37) | ADAM17MMP1ANPEPMMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |