Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 11/20 | 0.59 |
| ▸ | MMP2 | P08253 | 9/20 | 0.59 |
| ▸ | MMP8 | P22894 | 9/20 | 0.59 |
| ▸ | MMP9 | P14780 | 7/20 | 0.59 |
| ▸ | MMP1 | P03956 | 5/20 | 0.59 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.59 |
| ▸ | MMP3 | P08254 | 2/20 | 0.59 |
| ▸ | MMP7 | P09237 | 2/20 | 0.59 |
| ▸ | MMP14 | P50281 | 2/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | MMP10 | P09238 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946607 | 0.89 | SMN1; SMN2 (0.47) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL6946625 | 0.85 | MAPT (0.46) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL6946993 | 0.84 | SMN1; SMN2 (0.44) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL6727302 | 0.81 | MMP13 (0.64) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL6953375 | 0.81 | SMN1; SMN2 (0.46) | MMP13MMP2MMP8MMP9MMP1 | |
| Cts-1027 SCHEMBL2381112 | 0.75 | MMP1 (1.00) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL6727303 | 0.73 | MMP13 (0.62) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL15505956 | 0.70 | MMP1 (0.81) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL6947449 | 0.70 | HRH3 (0.46) | MMP13MMP2MMP8MMP9MMP1 | |
| SCHEMBL6727248 | 0.69 | MMP13 (0.52) | MMP13MMP2MMP8MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | claimed |