Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 4/20 | 0.39 |
| ▸ | MMP13 | P45452 | 4/20 | 0.39 |
| ▸ | MMP9 | P14780 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP8 | P22894 | 3/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | MMP7 | P09237 | 2/20 | 0.39 |
| ▸ | MMP14 | P50281 | 2/20 | 0.39 |
| ▸ | MMP10 | P09238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946993 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1RAB9AATMHRH3 | |
| SCHEMBL6946607 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1RAB9AATMHRH3 | |
| SCHEMBL6976767 | 0.81 | USP2 (0.45) | SMN1; SMN2L3MBTL1HRH3USP2MMP1 | |
| SCHEMBL6945635 | 0.81 | MMP13 (0.59) | SMN1; SMN2L3MBTL1MMP1MMP13MMP9 | |
| SCHEMBL6946625 | 0.80 | MAPT (0.46) | SMN1; SMN2L3MBTL1RAB9AATMHRH3 | |
| SCHEMBL6969747 | 0.72 | MMP13 (0.50) | L3MBTL1MMP1MMP13MMP9MMP2 | |
| SCHEMBL6952614 | 0.69 | MMP13 (0.52) | SMN1; SMN2HRH3MMP1MMP13MMP9 | |
| SCHEMBL6946483 | 0.68 | MEN1 (0.46) | SMN1; SMN2L3MBTL1RAB9AATMHRH3 | |
| SCHEMBL6735645 | 0.68 | MMP1 (0.47) | SMN1; SMN2L3MBTL1USP2MMP1MMP13 | |
| SCHEMBL6948498 | 0.66 | MEN1 (0.43) | SMN1; SMN2L3MBTL1RAB9AATMHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | claimed |