Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 3/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | FDPS | P14324 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948977 | 0.83 | PLA2G7 (0.53) | PLA2G7MMP2MMP3MMP9MMP13 | |
| SCHEMBL6948787 | 0.81 | PLA2G7 (0.53) | PLA2G7MMP2MMP3MMP9MMP13 | |
| SCHEMBL6945719 | 0.79 | PLA2G7 (0.50) | PLA2G7MMP2MMP3MMP9MMP13 | |
| SCHEMBL6943124 | 0.78 | MMP2 (0.54) | PLA2G7MMP2MMP3MMP9MMP13 | |
| SCHEMBL6943312 | 0.74 | PLA2G7 (0.43) | PLA2G7MMP2MMP3MMP9MMP13 | |
| SCHEMBL6946800 | 0.70 | MMP2 (0.49) | PLA2G7MMP2MMP3MMP9MMP13 | |
| SCHEMBL7977189 | 0.69 | PLA2G7 (0.39) | PLA2G7MMP2MMP3MMP9MMP13 | |
| SCHEMBL6943165 | 0.67 | MMP3 (0.46) | PLA2G7MMP2MMP3MMP9MMP13 | |
| SCHEMBL6948525 | 0.67 | PLA2G7 (0.54) | PLA2G7MMP2MMP3MMP9MMP13 | |
| SCHEMBL6948808 | 0.67 | MMP3 (0.38) | PLA2G7MMP2MMP3MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | claimed |