Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 8/20 | 0.33 |
| ▸ | MMP9 | P14780 | 8/20 | 0.33 |
| ▸ | MMP3 | P08254 | 7/20 | 0.33 |
| ▸ | MMP1 | P03956 | 7/20 | 0.33 |
| ▸ | MMP13 | P45452 | 7/20 | 0.33 |
| ▸ | MMP7 | P09237 | 2/20 | 0.33 |
| ▸ | MMP14 | P50281 | 2/20 | 0.33 |
| ▸ | MMP8 | P22894 | 5/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974063 | 0.85 | PLA2G7 (0.38) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL6946388 | 0.76 | MMP2 (0.40) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL4827863 | 0.72 | PLA2G7 (0.46) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL1593903 | 0.72 | PLA2G7 (0.45) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL7425977 | 0.71 | PLA2G7 (0.34) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL5036973 | 0.71 | PLA2G7 (0.46) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL8019774 | 0.70 | PLA2G7 (0.46) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL6945464 | 0.69 | PLA2G7 (0.49) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL7603860 | 0.69 | PLA2G7 (0.40) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL7221727 | 0.69 | MMP2 (0.37) | PLA2G7NR1H2NR1H3MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187924-B1 | INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TUMOR NECROSIS FACTOR-ALPHA-MEDIATED DISEASES | DARWIN DISCOVERY, LTD. (GB) | 2001-02-13 | — | — | US | disclosed |