Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 8/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7245462 | 0.88 | MAPT (0.60) | MAPTTP53POLBALOX15 | |
| SCHEMBL6951137 | 0.81 | MAPT (0.55) | MAPTTP53POLBALOX15 | |
| SCHEMBL27424745 | 0.80 | POLB (0.42) | MAPTTP53POLBALOX15 | |
| SCHEMBL6951542 | 0.75 | MAPT (0.49) | MAPTTP53POLBALOX15 | |
| SCHEMBL9210940 | 0.72 | ALOX15 (0.43) | ALOX15 | |
| SCHEMBL8914575 | 0.72 | TP53 (0.49) | MAPTTP53 | |
| SCHEMBL7241732 | 0.70 | MAPT (0.68) | MAPTTP53POLBALOX15 | |
| SCHEMBL9246649 | 0.69 | MAPT (0.67) | MAPTTP53POLBALOX15 | |
| SCHEMBL11117565 | 0.67 | NR3C2 (0.44) | MAPTTP53POLB | |
| SCHEMBL8084184 | 0.67 | MAPT (0.63) | MAPTTP53POLBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657432-B1 | Phenyl-substituted 1,4-dihydropyridines with cerebral activity | BAYER AG (DE) | 2003-03-12 | — | — | EP | disclosed |
| EP-0657431-B1 | 4-Phenyl-3-substituted 1,4-dihydropyridine esters with cerebral activity | BAYER AG (DE) | 2003-02-19 | — | — | EP | disclosed |
| EP-0657432-A1 | Phenyl-substituted 1,4-dihydropyridines with cerebral activity | BAYER AG (DE) | 1995-06-14 | — | — | EP | disclosed |
| EP-0657431-A1 | 4-Phenyl-3-substituted 1,4-dihydropyridine esters with cerebral activity | BAYER AG (DE) | 1995-06-14 | — | — | EP | disclosed |